We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
New insights into human enteric neuropathies.
- Authors
De Giorgio, R.; Guerrini, S.; Barbara, G.; Cremon, C.; Stanghellini, V.; Corinaldesi, R.
- Abstract
The functioning of enteric neuronal circuitries has been elucidated in the recent past. Evidence is now gathering to explain how dysfunction of the enteric nervous system (ENS) may lead to human gastrointestinal motor disorders. These conditions include achalasia, congenital hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction, Hirschsprung's disease, chronic idiopathic constipation, and probably irritable bowel syndrome. Degenerative, inflammatory and genetic mechanisms exert a critical role in ENS dysfunction underlying gut dysmotility. The study of the ENS abnormalities in gut dysmotility provides a framework to better understand the mechanisms involved in degeneration and neuronal loss and fosters the development of targeted therapeutic options.
- Subjects
INTESTINAL infections; CONSTIPATION; NERVOUS system; NEUROPATHY; NEUROSCIENCES
- Publication
Neurogastroenterology & Motility, 2004, Vol 16, p143
- ISSN
1350-1925
- Publication type
Article
- DOI
10.1111/j.1743-3150.2004.00491.x