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- Title
High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients.
- Authors
WAGGIALLAH, H. A.; ELTAYEB, M. M.; HJAZI, A. M.; ELMOSAAD, Y. M.
- Abstract
OBJECTIVE: The purpose of the present study is to see if the presence of angiotensin- converting enzyme 2 (ACE-2), transmembrane serine protease 2 (TMPRSS), and P-selectin in platelets increases the risk of thrombosis in COVID-19 patients. PATIENTS AND METHODS: This was a cross-sectional study conducted in the COVID-19 isolation center between January and September 2021 and comprised 61 COVID-19-infected patients, 21 of whom were in the intensive care unit (ICU) and 40 of whom were non-ICU patients (non-ICUP) in the isolation center. The coagulation profile, as well as the ACE-2, TMPRES, and P-selectin receptors, were all assessed in addition to the complete blood count (CBC). A questionnaire was also utilized to collect social and demographic data. RESULTS: All platelet indices and coagulation profiles were significantly altered in COVID-19 ICUP and non-ICUP in this research; additionally, there is a significant association between the presence of ACE-2, P-selectin, and TMPRRS2 in COVID-19 patients with coagulation profile and platelet indices leading to hypercoagulable state. CONCLUSIONS: In summary, the interaction of ACE-2, TMPRSS, and P-selectin in platelets appears to be a key element contributing to COVID-19 severity via their impact on thrombus development. Further investigation into these pathways may provide possible treatment targets for reducing the severe consequences of the COVID-19 infection.
- Subjects
COVID-19; THROMBOTIC thrombocytopenic purpura; BLOOD cell count; BLOOD coagulation factors; SERINE; INTENSIVE care units; ANGIOTENSIN converting enzyme; THROMBOPOIETIN receptors
- Publication
European Review for Medical & Pharmacological Sciences, 2024, Vol 28, Issue 5, p1847
- ISSN
1128-3602
- Publication type
Article