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- Title
Drug Interaction between Rifampicin, Isoniazid and Cotrimoxazole in Rabbits.
- Authors
Malhi, R.; Uppal, R.; Sharma, P.L.
- Abstract
1 The results of cotrimoxazole (CTZ) co-administration (15 mg kg-1 trimethoprim + 40 mg kg-1 sulphamethoxazole) on plasma concentration and various pharmacokinetic parameters of rifampicin (RIF, 24 mg kg-1) and isoniazid (INH, 14 mg kg-1) were studied.2 In the test group (n = 6), CTZ was administered on the 24th day of antitubercular treatment (ATT) and given for 7 d.3 At the end of concurrent treatment with CTZ, RIF half-life (t½) and plasma concentration were both increased. However, there was no effect on INH half-life and plasma concentration.
- Publication
Human & Experimental Toxicology, 1992, Vol 11, Issue 2, p105
- ISSN
0960-3271
- Publication type
Article
- DOI
10.1177/096032719201100208