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- Title
Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia.
- Authors
Xue Bai; Jianxin Yang; Guiqin Liu; Junbo Zhu; Qian Wang; Wenqi Gu; Linli La; Xiangyang Li
- Abstract
Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia-gut microbiota-CYP450/drug transporter axis is emerging as a vital factor in drug metabolism. However, the mechanisms through which the gut microbiota mediates the regulation of CYP450/drug transporters under high-altitude hypoxia have not been well defined. In this study, we investigated the mechanisms underlying gut microbial changes in response to hypoxia. We compared 16S ribosomal RNA gene sequences of the gut microbiota from plain and hypoxic rats. As a result, we observed an altered gut microbial diversity and composition in rats under hypoxia. Our findings show that dysregulated gut microbiota changes CYP3A1 and MDR1 expressions in high-altitude hypoxic environments. Thus, our study reveals a novel mechanism underlying the functioning of the hypoxia-gut microbiota-CYP450/drug transporter axis.
- Subjects
GUT microbiome; HYPOXEMIA; DRUG laws; DRUG metabolism; RIBOSOMAL RNA; NITROIMIDAZOLES
- Publication
Frontiers in Pharmacology, 2022, Vol 13, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2022.977370