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- Title
Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.
- Authors
Neyrinck, Audrey M.; Rodriguez, Julie; Zhang, Zhengxiao; Seethaler, Benjamin; Sánchez, Cándido Robles; Roumain, Martin; Hiel, Sophie; Bindels, Laure B.; Cani, Patrice D.; Paquot, Nicolas; Cnop, Miriam; Nazare, Julie-Anne; Laville, Martine; Muccioli, Giulio G.; Bischoff, Stephan C.; Walter, Jens; Thissen, Jean-Paul; Delzenne, Nathalie M.
- Abstract
Purpose: Inulin-type fructans (ITF) are prebiotic dietary fibre (DF) that may confer beneficial health effects, by interacting with the gut microbiota. We have tested the hypothesis that a dietary intervention promoting inulin intake versus placebo influences fecal microbial-derived metabolites and markers related to gut integrity and inflammation in obese patients. Methods: Microbiota (16S rRNA sequencing), long- and short-chain fatty acids (LCFA, SCFA), bile acids, zonulin, and calprotectin were analyzed in fecal samples obtained from obese patients included in a randomized, placebo-controlled trial. Participants received either 16 g/d native inulin (prebiotic n = 12) versus maltodextrin (placebo n = 12), coupled to dietary advice to consume inulin-rich versus inulin-poor vegetables for 3 months, in addition to dietary caloric restriction. Results: Both placebo and prebiotic interventions lowered energy and protein intake. A substantial increase in Bifidobacterium was detected after ITF treatment (q = 0.049) supporting our recent data obtained in a larger cohort. Interestingly, fecal calprotectin, a marker of gut inflammation, was reduced upon ITF treatment. Both prebiotic and placebo interventions increased the ratio of tauro-conjugated/free bile acids in feces. Prebiotic treatment did not significantly modify fecal SCFA content but it increased fecal rumenic acid, a conjugated linoleic acid (cis-9, trans-11 CLA) with immunomodulatory properties, that correlated notably to the expansion of Bifidobacterium (p = 0.031; r = 0.052). Conclusions: Our study demonstrates that ITF-prebiotic intake during 3 months decreases a fecal marker of intestinal inflammation in obese patients. Our data point to a potential contribution of microbial lipid-derived metabolites in gastro-intestinal dysfunction related to obesity. ClinicalTrials.gov Identifier: NCT03852069 (February 22, 2019 retrospectively, registered).
- Subjects
OBESITY; DIETARY fiber; BIOMARKERS; PREBIOTICS; INFLAMMATION; GUT microbiome; INGESTION; FECES; RANDOMIZED controlled trials; IMMUNOLOGICAL adjuvants; STATISTICAL sampling; METABOLITES; FATTY acids
- Publication
European Journal of Nutrition, 2021, Vol 60, Issue 6, p3159
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-021-02484-5