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- Title
Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751.
- Authors
Yu, Jiaming; Guo, Hui; Zhang, Jing; Hu, Jiansen; He, Hongtao; Chen, Caixia; Yang, Na; Yang, Fan; Lin, Zexu; Dai, Huanqin; Ouyang, Liming; Liu, Cuihua; Lei, Xiaoguang; Zhang, Lixin; Zhu, Guoliang; Song, Fuhang
- Abstract
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.
- Subjects
POLYKETIDES; STREPTOMYCES; MULTIDRUG-resistant tuberculosis; MYCOBACTERIUM tuberculosis; SEDIMENT sampling; BIOMIMETIC synthesis; FLAVONOID glycosides; GLYCOSIDES
- Publication
Marine Drugs, 2024, Vol 22, Issue 6, p259
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22060259