We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting.
- Authors
Isler, Burcu; Özer, Berna; Çınar, Güle; Aslan, Abdullah Tarık; Vatansever, Cansel; Falconer, Caitlin; Dolapçı, İştar; Şimşek, Funda; Tülek, Necla; Demirkaya, Hamiyet; Menekşe, Şirin; Akalin, Halis; Balkan, İlker İnanç; Aydın, Mehtap; Tigen, Elif Tükenmez; Demir, Safiye Koçulu; Kapmaz, Mahir; Keske, Şiran; Doğan, Özlem; Arabacı, Çiğdem
- Abstract
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
- Subjects
TURKEY; CARBAPENEM-resistant bacteria; COHORT analysis; CARBAPENEMASE; LONGITUDINAL method; REGRESSION analysis
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2022, Vol 41, Issue 5, p841
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-022-04425-4