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- Title
New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle.
- Authors
Yu, Jia-Dong; Yu, Dan-Dan; Su, Ming-Zhi; Gu, Yu-Cheng; Wang, Hong; Guo, Yue-Wei
- Abstract
Fifteen new diterpenoids, namely xishaklyanes A-O (1–15), along with three known related ones (16–18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds was elucidated by a combination of detailed spectroscopic analyses, chemical derivatization, quantum chemical calculations, and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher's method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 μg/mL against Lactococcus garvieae.
- Subjects
ALCYONACEA; DITERPENES; STEREOCHEMISTRY; PATHOGENIC bacteria; ANTIBACTERIAL agents
- Publication
Marine Drugs, 2023, Vol 21, Issue 6, p362
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md21060362