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- Title
Monitoramento do processo de compressão de ibuprofeno utilizando controle estatístico.
- Authors
Bianchi, Sara Elis; Borges de Souza, Kellen Cristhinia
- Abstract
The statistical process control (SPC) is a widely used tool to assist in quality control physical parameters like weight, hardness and friability. Through the control charts it is possible to detect deviations of process parameters, reducing the amount of products out of specification and, consequently, costs of production. The evaluation of thirty lots of ibuprofen in a pharmaceutical company using statistical process control has enabled the provision of essential information for the detailed investigation of the critical points of the process, diagnosing the possible non-conformities in the compression step of the drug. Thus, one can offer improvement activities by identifying and eliminating special causes of variation in the process, in order to produce quality tablets.
- Subjects
STATISTICAL process control; INDUSTRIAL costs; DRUGS; NONSTEROIDAL anti-inflammatory agents; IBUPROFEN
- Publication
Revista de Ciências Farmacêuticas Básica e Aplicada, 2012, Vol 33, Issue 2, p255
- ISSN
1808-4532
- Publication type
Article