We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recent Computational Insights into the Oxygen Activation by Copper-Dependent Metalloenzymes.
- Authors
Wang, Zhanfeng; Fang, Wenhan; Peng, Wei; Wu, Peng; Wang, Binju
- Abstract
Dioxygen (O2) is a key component of the earth's atmosphere and is essential for life activities on the planet. Upon O2 activation, metalloenzymes are able to mediate various oxidative transformations related to many biosynthesis and metabolism processes. In this mini-review, we focus on the recent computational insights into the oxygen activation by several copper-dependent enzymes, including mono-copper enzyme lytic polysaccharide monooxygenase (LPMO), particulate methane monooxygenase (pMMO), as well as the binuclear copper enzymes peptidylglycine α-hydroxylating monooxygenase (PHM) and dopamine beta-monooxygenase (DβM). Understanding the structure–function relationships of these enzymes is of fundamental importance in chemistry and biology, and is also beneficial to engineering of these metalloenzymes for new functions.
- Subjects
METALLOENZYMES; COPPER enzymes; LYSINS; MONOOXYGENASES; BIOSYNTHESIS; DOPAMINE receptors
- Publication
Topics in Catalysis, 2022, Vol 65, Issue 1-4, p187
- ISSN
1022-5528
- Publication type
Article
- DOI
10.1007/s11244-021-01444-x