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- Title
Coiled-coils: The long and short of it.
- Authors
Truebestein, Linda; Leonard, Thomas A.
- Abstract
Coiled-coils are found in proteins throughout all three kingdoms of life. Coiled-coil domains of some proteins are almost invariant in sequence and length, betraying a structural and functional role for amino acids along the entire length of the coiled-coil. Other coiled-coils are divergent in sequence, but conserved in length, thereby functioning as molecular spacers. In this capacity, coiled-coil proteins influence the architecture of organelles such as centrioles and the Golgi, as well as permit the tethering of transport vesicles. Specialized coiled-coils, such as those found in motor proteins, are capable of propagating conformational changes along their length that regulate cargo binding and motor processivity. Coiled-coil domains have also been identified in enzymes, where they function as molecular rulers, positioning catalytic activities at fixed distances. Finally, while coiled-coils have been extensively discussed for their potential to nucleate and scaffold large macromolecular complexes, structural evidence to substantiate this claim is relatively scarce.
- Subjects
INDUCTION coils; AMINO acid synthesis; PHYSIOLOGICAL effects of amino acids; GOLGI apparatus; PROTEIN genetics; PHYSIOLOGY
- Publication
BioEssays, 2016, Vol 38, Issue 9, p903
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.201600062