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- Title
Understanding Redox Homeostasis and Its Role in Cancer.
- Authors
SHRIRAM DAWANE, JAYSHREE; ANIL PANDIT, VIJAYA
- Abstract
When a cell is damaged or altered without repair to its system, it usually dies. But if such damaged or unrepaired cells do not die and proliferate with uncontrolled growth; a mass of cancer cells develop. Cancer has a complex aetiology with multiple risk factors that involve the interplay between genetic and environmental influences. The redox dysregulation originates from metabolic alterations and it is dependent on mitogenic and survival signalling through reactive oxygen species. There is a delicate balance between the production and the destruction of reactive species; for this, we need to understand the role of redox homeostasis in cancer. So, the specific vulnerability of the malignant cells can be selectively targeted. This article will outline the redox homeostasis and the relationship between the disturbances in it and cancer.
- Subjects
ETIOLOGY of diseases; PHYSIOLOGICAL control systems; CANCER cells; HOMEOSTASIS; CELLULAR pathology
- Publication
Journal of Clinical & Diagnostic Research, 2012, Vol 6, Issue 10, p1796
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2012/4947.2654