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- Title
Advanced soft-tissue sarcoma and treatment options: critical appraisal of trabectedin.
- Authors
Desar, Ingrid M. E.; Constantinidou, Anastasia; Kaal, Suzanne E. J.; Jones, Robin L.; van der Graaf, Winette T. A.
- Abstract
Soft-tissue sarcomas (STS) are a heterogeneous group of rare solid tumors of mesenchymal origin. This paper reviews the current status of systemic treatment in advanced and metastatic soft tissue sarcomas, with an emphasis on trabectedin. Trabectedin is a unique type of chemotherapeutic agent with multiple potential mechanisms of action. We discuss the putative mechanisms, as well as the toxicity and administration schedules of trabectedin, followed by its efficacy in first-line systemic therapy and beyond first-line systemic therapy.
- Subjects
SOFT tissue tumors; CANCER treatment; SARCOMA; TRABECTEDIN; DRUG efficacy; CANCER chemotherapy; HEALTH outcome assessment; TUMOR treatment
- Publication
Cancer Management & Research, 2016, Vol 8, p95
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S86746