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- Title
Verruculosins A–B, New Oligophenalenone Dimers from the Soft Coral-Derived Fungus Talaromyces verruculosus.
- Authors
Wang, Minghui; Yang, Longhe; Feng, Liubin; Hu, Fan; Zhang, Fang; Ren, Jie; Qiu, Yan; Wang, Zhaokai
- Abstract
In an effort to discover new bioactive anti-tumor lead compounds, a specific tyrosine phosphatase CDC25B and an Erb family receptor EGFR were selected as drug screening targets. This work led to the investigation of the soft coral-derived fungus Talaromyces verruculosus and identification of two new oligophenalenone dimers, verruculosins A–B (1–2), along with three known analogues, bacillisporin F (3), duclauxin (4), and xenoclauxin (5). Compound 1 was the first structure of the oligophenalenone dimer possessing a unique octacyclic skeleton. The detailed structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic data, X-ray crystallography, optical rotation, Electronic Circular Dichroism (ECD) analysis, and nuclear magnetic resonance (NMR) calculations. Among which, compounds 1, 3, and 5 exhibited modest inhibitory activity against CDC25B with IC50 values of 0.38 ± 0.03, 0.40 ± 0.02, and 0.26 ± 0.06 µM, respectively.
- Subjects
TALAROMYCES; DIMERS; NUCLEAR magnetic resonance; OPTICAL rotation; FUNGI; PROTEIN-tyrosine phosphatase
- Publication
Marine Drugs, 2019, Vol 17, Issue 9, p516
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17090516