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- Title
Hereditary Hemochromatosis: Time for Targeted Screening.
- Authors
Phatak, Pradyumna D.; Bonkovsky, Herbert L.; Kowdley, Kris V.
- Abstract
The discovery of the HFE gene in 1996 heralded a decade of major advances in the understanding of the mechanisms that control iron absorption and body iron stores. A genetic definition of the common form of hereditary hemochromatosis became possible, and testing for the common causative HFE mutations is now widely available in clinical laboratories. Several population screening studies have confirmed that disease penetrance in HFE-related hereditary hemochromatosis is lower than previously believed, making universal population-based screening for this disorder unattractive. However, hereditary hemochromatosis may still cause morbidity and mortality because of iron overload. Early detection and use of appropriate therapy can prevent these manifestations and can only be achieved by targeted case finding. In this article, the authors draw attention again to hereditary hemochromatosis as a cause of preventable organ dysfunction and propose targeted case finding for Caucasian men of Northern European ancestry.
- Subjects
HEMOCHROMATOSIS; IRON metabolism disorders; INBORN errors of metabolism; MEDICAL screening; FAMILIAL diseases; GENETIC disorders
- Publication
Annals of Internal Medicine, 2008, Vol 149, Issue 4, p270
- ISSN
0003-4819
- Publication type
Article
- DOI
10.7326/0003-4819-149-4-200808190-00009