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- Title
Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus Trichoderma asperellum cf44-2.
- Authors
Miao, Feng-Ping; Fang, Sheng-Tao; Yin, Xiu-Li; Ji, Nai-Yun; Song, Yin-Ping
- Abstract
One new bisabolane sesquiterpene, bisabolan-1,10,11-triol (<bold>1</bold>), one new norbisabolane sesquiterpene, 12-nor-11-acetoxybisabolen-3,6,7-triol (<bold>2</bold>), two new naturally occurring monoterpenes, (7<italic>S</italic>)- and (7<italic>R</italic>)-1-hydroxy-3-<italic>p</italic>-menthen-9-oic acids (<bold>3</bold> and <bold>4</bold>), one new naturally occurring trichodenone, dechlorotrichodenone C (<bold>5</bold>), one new chlorine-containing trichodenone, 3-hydroxytrichodenone C (<bold>6</bold>), one new diketopiperazine, methylcordysinin A (<bold>7</bold>), and one new naturally occurring oxazole derivative, 4-oxazolepropanoic acid (<bold>8</bold>), were isolated from the culture of a marine brown alga-endophytic strain (cf44-2) of <italic>Trichoderma asperellum</italic>. Their structures and relative configurations were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of <bold>3</bold>–<bold>6</bold> were assigned by analysis of the ECD spectra aided by quantum chemical computations. Compounds <bold>1</bold>, <bold>2</bold>, <bold>5</bold>, and <bold>6</bold> showed growth inhibition of some marine phytoplankton species and pathogenic bacteria.
- Subjects
TRICHODERMA; METABOLITE analysis; FUNGAL metabolites; HALOGENATION; TERPENES
- Publication
Marine Drugs, 2018, Vol 16, Issue 8, p266
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md16080266