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- Title
Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study.
- Authors
Ryosuke Kitahata; Shinichiro Nakajima; Hiroyuki Uchida; Tetsu Hayashida; Maiko Takahashi; Shintaro Nio; Jinichi Hirano; Maki Nagaoka; Takefumi Suzuki; Hiromitsu Jinno; Yuko Kitagawa; Masaru Mimura
- Abstract
Purpose: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy. Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions. Results: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions. Conclusion: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions.
- Subjects
BREAST cancer treatment; COGNITIVE ability; CANCER chemotherapy; SELF-evaluation; LONGITUDINAL method
- Publication
Neuropsychiatric Disease & Treatment, 2017, Vol 13, p2489
- ISSN
1176-6328
- Publication type
Article
- DOI
10.2147/NDT.S141408