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- Title
Reproductive life events and Alzheimer's disease in Italian women: a retrospective study.
- Authors
Zucchella, Chiara; Sinforiani, Elena; Citterio, Antonietta; Giarracca, Valentina; Bono, Giorgio; Mauri, Marco
- Abstract
The aim of our study was to understand the complex relationship between the major reproductive life events in women with Alzheimer's disease. In a retrospective, case-control study, 275 women with Alzheimer's disease (AD) and 276 control patients from a hospital population were enrolled from July 2007 to December 2010. The AD patients presented with later menopause (P , 0.01), lower occurrence of surgical menopause (P , 0.04), reduced hormone-replacement therapy intake (P , 0.0001), and a longer reproductive life span (P , 0.01), compared to controls. No significant differences were found with respect to age at puberty, number of pregnancies, previous abortions, or contraceptive therapy. A higher education level appeared to have a protective role against the risk of developing AD. In women, menopause and hormone-replacement therapy can differentially modulate the clinical manifestations of AD, but these factors do not play a predictive role in its development.
- Subjects
ITALY; RETROSPECTIVE studies; ALZHEIMER'S disease; WOMEN'S mental health; HEALTH outcome assessment
- Publication
Neuropsychiatric Disease & Treatment, 2012, Vol 8, p555
- ISSN
1176-6328
- Publication type
Article
- DOI
10.2147/NDT.S36622