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- Title
Comparison of hypertonic saline versus normal saline on cytokine profile during CABG.
- Authors
Mazandarani, Mahnaz; Yousefshahi, Fardin; Abdollahi, Mohammad; Hamishehkar, Hadi; Barkhordari, Khosro; Ali Boroomand, Mohammad; Jalali, Arash; Ahmadi, Arezoo; Shariat Moharari, Reza; Bashirzadeh, Mona; Mojtahedzadeh, Mojtaba
- Abstract
Background and the purpose of the study: Blood contact with artificial surfaces of the extracorporeal circuit and ischemia-reperfusion injury in CABG with CPB, may lead to a systemic inflammatory response. Hypertonic saline have been recently investigated as a fluid in order to decrease inflammatory response and cytokines generation in patients undergo cardiac operations. Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients. Methods: The present study is a randomized double-blinded clinical trial. 40 patients undergoing CABG were randomized to receive HS 5% or NS before operation. Blood samples were obtained after receiving HS or NS, just before operation, 24 and 48 hours post-operatively. Plasma levels of IL-6 and IL-10 were measured by ELISA. Results and major conclusion: Patients received HS had lower levels of IL-6 and higher level of IL-10 compared with NS group, however these differences were not statistically significant. Results of this study suggest that pre-treatment with small volume hypertonic saline 5% may have beneficial effects on inflammatory response following CABG operation.
- Subjects
HYPERTONIC saline solutions; ANALYSIS of variance; CHI-squared test; COMPARATIVE studies; CORONARY artery bypass; ENZYME-linked immunosorbent assay; HYPERTONIC solutions; INFLAMMATION; INTERLEUKINS; PHYSIOLOGIC salines; RESEARCH funding; T-test (Statistics); U-statistics; RANDOMIZED controlled trials; REPEATED measures design; BLIND experiment; DATA analysis software
- Publication
DARU: Journal of Pharmaceutical Sciences, 2012, Vol 20, p1
- ISSN
1560-8115
- Publication type
Article
- DOI
10.1186/2008-2231-20-49