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- Title
Identification of the occurrence of cardiotoxic effects by assessing left ventricular dysfunction and vascular remodeling parameters in a patient with acute lymphoblastic leukemia.
- Authors
Militaru, Anda; Militaru, Marius; Iurciuc, Mircea; Delamarian, Maria; Matusz, Petru; Lighezan, Daniel
- Abstract
Therapies for different malignancies are associated with an increased risk of cardiotoxicity. Amongst these drugs, anthracyclines and their analogs are most commonly used as chemotherapy agents but, unfortunately, they increase the incidence of cardiovascular side effects. Cardiovascular side effects induced by chemotherapy are highly associated with the cumulative dose of anticancer drugs. Left ventricular disfunction followed by cardiac failure are most frequent side effects of chemotherapy. We evaluated here cardiac disfunction and vascular changes for a young patient without cardiovascular risk factors before, diagnosed with acute lymphoblastic leukemia (ALL), three months after starting chemotherapy and three months after stem cell transplantation. Occurrence of left ventricular dysfunction, without any clinical signs after chemotherapy was reported. Small changes in vascular remodeling parameters have also been identified, which may suggest a more rapid vascular remodeling in patients receiving chemotherapy and radiotherapy.
- Subjects
LYMPHOBLASTIC leukemia; LEFT heart ventricle; HEART physiology; STEM cell transplantation
- Publication
Romanian Journal of Cardiology, 2018, Vol 28, Issue 1, p27
- ISSN
1220-658X
- Publication type
Article