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- Title
Infant Formula with 50% or More of Palmitic Acid Bound to the sn-2 Position of Triacylglycerols Eliminate the Association between Formula-Feeding and the Increase of Fecal Palmitic Acid Levels in Newborns: An Exploratory Study.
- Authors
Shoji, Hiromichi; Arai, Hiroko; Kakiuchi, Satsuki; Ito, Atsushi; Sato, Keigo; Jinno, Shinji; Takahashi, Naoto; Masumoto, Kenichi; Yoda, Hitoshi; Shimizu, Toshiaki
- Abstract
The binding ratio of palmitic acid (PA) at the sn-2 position of triacylglycerols in infant formulas is lower than that in breast milk, resulting in higher levels of fecal PA. Even if the ratio is increased to 40–50%, fecal PA levels in formula-fed infants remain higher than those in breast–fed infants. In Japan, infant formulas with 50% or more of PA bound to sn-2 (high sn-2 PA milk) are commercially available; however, their effects on PA excretion have not been investigated. Therefore, this observational study aimed to preliminarily evaluate whether the feeding volume of high sn-2 PA milk is significantly associated with fecal total/soaped PA levels in newborns. Infant formulas were classified as high (≥50% of PA bound to sn-2) or low sn-2 (<50%) PA milk. Associations between feeding volume of high or low sn-2 PA milk and fecal PA levels were evaluated using multiple regression analysis models. The results showed that the feeding volume of low sn-2 PA milk was positively associated with fecal total/soaped PA levels, while there was no significant association between those of high sn-2 PA milk and fecal total/soaped PA levels. Our preliminary study suggests that high sn-2 PA milk may reduce increased fecal PA levels in formula-fed newborns.
- Subjects
JAPAN; FECAL analysis; RESEARCH funding; SCIENTIFIC observation; MULTIPLE regression analysis; TREATMENT effectiveness; MILK; INFANT formulas; INFANT nutrition; TRIGLYCERIDES; FATTY acids; DIETARY supplements
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1558
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111558