We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Validation and Application of Screen-Printed Microchip for Potentiometric Determination of Metformin Hydrochloride in Tablet Dosage Form.
- Authors
Alqarni, Mohammed; Alshehri, Abdullah A.; Arida, Hassan
- Abstract
Metformin is an oral biguanides hypoglycaemic agent, which used to lower the blood glucose levels in people with type 2 diabetes mellitus. Many analytical techniques have been used to quantify the drug in different pharmaceutical dosage forms; however, most of these methods have limited throughput in the quality control application. A disposable potentiometric microsensor responsive to metformin has recently been reported. For the first time, herein, this method of analysis has been validated according to IUPAC recommendations and successfully applied in the determination of metformin drug in some dosage form. Different drug formulations of metformin hydrochloride have been collected from the local pharmaceutical stores in Saudi Arabia and analysed using the validated microchip-based method of analysis. Subsequently, the results of this study showed that the validated method was linear, specific, precise, and accurate. The linear range was 1 × 10−1–1 × 10−5 mol L−1 and the correlation coefficient was 0.999. The limit of detection was 2.89 × 10−6 mol L−1, and the limit of quantification was 8.77 × 10−6 mol L−1. This method demonstrated high precision, with an RSD% of less than 2.22%. The accuracy of this method was obtained by comparing the recovery percentage with percentage values less than 5%. The results obtained showed that there was no significant difference between the references, label, and recovery of less than 5%.
- Subjects
SAUDI Arabia; METFORMIN; HYDROCHLOROTHIAZIDE; DOSAGE forms of drugs; TYPE 2 diabetes; ELECTROCHEMICAL sensors; INTEGRATED circuits
- Publication
International Journal of Analytical Chemistry, 2024, Vol 2024, p1
- ISSN
1687-8760
- Publication type
Article
- DOI
10.1155/2024/8664723