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- Title
EVALUATION OF THE UPTAKE OF CDDP-CONTAINING POLYMERIC MICELLES IN SINGLE PANCREATIC CANCER CELLS.
- Authors
MIZUNO, K.; UESAKA, M.; MATSUYAMA, S.; ITO, Y.; ISHII, K.; YAMAZAKI, H.
- Abstract
Highly functionalized drugs delivered via a drug delivery system are expected to have less side effects and higher accumulation rates compared to conventional anticancer drugs. An understanding of the kinetics of drugs contained within a delivery system is necessary to obtain the maximum therapeutic effect. We performed micro-elemental analysis of human pancreatic cancer cells treated with cis-diamminedichloroplatinum(II) (CDDP)-containing polymeric micelles. The results showed that the platinum signals were distributed inside the cellular nuclei and the cytoplasm indicating that CDDP was delivered into the cells. The results from this study will be useful for designing an optimum carrier for platinum-containing anticancer drugs.
- Subjects
MICELLES; PANCREATIC cancer; CANCER cells; DRUG delivery systems; ANTINEOPLASTIC antibiotics
- Publication
International Journal of PIXE, 2010, Vol 20, Issue 1/2, p37
- ISSN
0129-0835
- Publication type
Article
- DOI
10.1142/S012908351000194X