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- Title
Targeted drug delivery system for oral cancer therapy using sonoporation.
- Authors
Maeda, Hironobu; Tominaga, Kazuhiro; Iwanaga, Kenjiro; Nagao, Fuminori; Habu, Manabu; Tsujisawa, Toshiyuki; Seta, Yuji; Toyoshima, Kuniaki; Fukuda, Jin‐ichi; Nishihara, Tatsuji
- Abstract
Ultrasound-mediated destruction of microbubbles has been proposed as an innovative non-invasive drug delivery system for cancer therapy. We developed a specific drug delivery system for squamous cell carcinoma that uses sonoporation with the anti-epidermal growth factor receptor (EGFR) antibody. Administration of a low dose of bleomycin (BLM) by sonoporation with the anti-EGFR antibody produced a marked growth inhibition of Ca9-22 cells in vitro. In addition, scanning electron microscopic analysis revealed apparent surface deformation of Ca9-22 cells treated with sonoporation in the presence of the antibody. Interestingly, the population of apoptotic cells was remarkably increased when a low dose of BLM was delivered using sonoporation with the Fab fragment of the anti-EGFR antibody. These findings indicate that sonoporation with the Fab fragment makes it possible to administer drugs into cells more efficiently and specifically, suggesting a novel application for chemotherapy and gene therapy treatments for oral squamous cell carcinoma.
- Subjects
DRUG delivery systems; TREATMENT of oral cancer; CANCER treatment; GENE therapy; IMMUNOSUPPRESSIVE agents; GROWTH factors; PHARMACEUTICAL technology; MEDICAL imaging systems
- Publication
Journal of Oral Pathology & Medicine, 2009, Vol 38, Issue 7, p572
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.2009.00759.x