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- Title
Comparative Study of Biological (Phoenix loureiroi Fruit) and Chemical Synthesis of Chitosan-Encapsulated Zinc Oxide Nanoparticles and their Biological Properties.
- Authors
Rajan, Murugan; Anthuvan, Allen Joseph; Muniyandi, Kasipandi; Kalagatur, Naveen Kumar; Shanmugam, Saravanan; Sathyanarayanan, Saikumar; Chinnuswamy, Viswanathan; Thangaraj, Parimelazhagan; Narain, Narendra
- Abstract
In the present study, the effect of in vitro antioxidant and cytotoxic properties was investigated in the biologically and chemically synthesized zinc oxide (ZnO)- and chitosan (CTS)-encapsulated ZnO (ZnO–CTS) nanoparticles. The nanoparticles were biologically synthesized using Phoenix loureiroi fruit and characterized using Fourier transform infrared, X-ray diffraction, scanning electron microscopy, field emission scanning transmission electron microscopy, energy-dispersive X-ray spectroscopy and ultra violet-diffuse reflectance spectroscopy. The biologically synthesized ZnO–CTS nanoparticles (B-ZnO–CTS) results revealed good chemical structure (H–N–H, O–H, C=O, Zn and O groups), crystalline size (18 nm), morphology (spherical), elemental composition (Zn = 61.10%; O = 25.86%; C = 13.04%) and optical properties (λ = 374 nm; Eg = 3.18 eV). The B-ZnO–CTS also exhibited higher DPPH· (IC50 = 419.32 µg/mL), ABTS·+ (45.61%), nitric oxide (21.28%), hydroxyl radical (77.10%) scavenging activities and superoxide anion radical production (27.89%). The cytotoxicity of B-ZnO–CTS revealed less hemolytic property (2.17%) and inhibited the Caco-2 cancerous cell viability (IC50 = 70.45 µg/mL). In conclusion, biological synthesis presents better prospects in pharmacotherapeutic applications in nano-herbal drug delivery.
- Subjects
CHEMICAL synthesis; SCANNING transmission electron microscopy; BIOSYNTHESIS; ZINC oxide synthesis; FIELD emission; ZINC oxide
- Publication
Arabian Journal for Science & Engineering (Springer Science & Business Media B.V. ), 2020, Vol 45, Issue 1, p15
- ISSN
2193-567X
- Publication type
Article
- DOI
10.1007/s13369-019-04174-1