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- Title
Tangeretin: a mechanistic review of its pharmacological and therapeutic effects.
- Authors
Ashrafizadeh, Milad; Ahmadi, Zahra; Mohammadinejad, Reza; Ghasemipour Afshar, Elham
- Abstract
To date, a large number of synthetic drugs have been developed for the treatment and prevention of different disorders, such as neurodegenerative diseases, diabetes mellitus, and cancer. However, these drugs suffer from a variety of drawbacks including side effects and low efficacy. In response to this problem, researchers have focused on the plant-derived natural products due to their valuable biological activities and low side effects. Flavonoids consist of a wide range of naturally occurring compounds exclusively found in fruits and vegetables and demonstrate a number of pharmacological and therapeutic effects. Tangeretin (TGN) is a key member of flavonoids that is extensively found in citrus peels. It has different favorable biological activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. In the present review, we discuss the various pharmacological and therapeutic effects of TGN and then, demonstrate how this naturally occurring compound affects signaling pathways to exert its impacts.
- Subjects
PHYTOTHERAPY; ANTI-inflammatory agents; ANTINEOPLASTIC agents; ANTIOXIDANTS; CELLULAR signal transduction; CITRUS; FLAVONOIDS; MEDICINAL plants; NEUROPROTECTIVE agents
- Publication
Journal of Basic & Clinical Physiology & Pharmacology, 2020, Vol 31, Issue 4, p1
- ISSN
0792-6855
- Publication type
Article
- DOI
10.1515/jbcpp-2019-0191