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- Title
A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization.
- Authors
YANMING WANG; JUNJIE MA; XINGUANG LIU; RIMING LIU; LINGLING XU; LI WANG; JIANNONG CEN; XIAOXIA CHU
- Abstract
Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid a-receptor (RARA) gene at 17q21. The PML-RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33-year-old male with APL carrying a potential complex translocation. The initial symptom was bleeding gums. Chromosomal analysis of the bone marrow cells revealed an atypical 17q aberration. Fluorescence in situ hybridization further indicated that 92% of analyzed cells were positive for the PML-RARA fusion gene. The patient experienced complete remission following treatment with arsenic trioxide and chemotherapy. The atypical translocations in acute promyelocytic leukemia require further investigation.
- Subjects
LEUKEMIA treatment; MYELOID leukemia; FLUORESCENCE; RETINOIC acid receptors; CANCER chemotherapy; IN situ hybridization
- Publication
Oncology Letters, 2016, Vol 12, Issue 6, p4717
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.5280