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- Title
miRNA-16 as a predictive factor for intracranial aneurysms in autosomal dominant polycystic kidney disease.
- Authors
Kulesza, Andrzej; Kulesza, Agnieszka; Fliszkiewicz, Magda; Łabuś, Anna; Pączek, Leszek; Niemczyk, Mariusz
- Abstract
Introduction. Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic renal disorder. It leads to multiple extra-renal complications, with intracranial aneurysms (IA) among the most serious. Biological markers could become tools in identifying patients at risk of an IA. MicroRNAs 16 (miR-16) and 25 (miR-25) have been proposed as being markers of IAs in the general population. In the current study, we attempted to discover if they may also be considered markers of IAs in ADPKD. Material and methods. 64 renal transplant recipients with ADPKD were included. After magnetic resonance angiography of the brain, they were divided into a case group (IA+, n = 13) and a control group (IA-, n = 51). Expression of miRNAs in plasma was analysed by qRT-PCR. Material and methods. 64 renal transplant recipients with ADPKD were included. After magnetic resonance angiography of the brain, they were divided into a case group (IA+, n = 13) and a control group (IA-, n = 51). Expression of miRNAs in plasma was analysed by qRT-PCR. Conclusions and clinical implications. MicroRNA-16 is a potential marker of IAs in renal transplant recipients with ADPKD. It may become a tool to identify patients who should undergo screening for an IA.
- Subjects
POLYCYSTIC kidney disease; HUMAN chromosome abnormalities; AUTOSOMAL recessive polycystic kidney; MICRORNA; NON-coding RNA
- Publication
Polish Journal of Neurology & Neurosurgery / Neurologia i Neurochirurgia Polska, 2021, Vol 55, Issue 3, p306
- ISSN
0028-3843
- Publication type
Article
- DOI
10.5603/PJNNS.a2021.0026