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- Title
Biologic Therapies in HIV/AIDS Patients with Inflammatory Diseases: A Systematic Review of the Literature.
- Authors
Bang, Alexander S.; Hakimi, Marwa; Tahir, Peggy; Bhutani, Tina; Leslie, Kieron S.
- Abstract
Biologic therapies have been increasingly developed and used for the treatment of severe inflammatory diseases. However, the safety and efficacy profile of biologic drugs in patients with HIV is not well established as this patient population is historically excluded from clinical trials. We review the available evidence of biologic use in people with HIV. We conducted a systematic review of the literature up to June 29, 2022 and included studies that treated patients with HIV who have inflammatory disease using biologic drugs. Clinical data regarding safety and efficacy were abstracted into tables. One hundred twelve studies were included, and 179 patients were included in our study. Nearly all classes of biologics drugs had a favorable safety profile with minimal or minor adverse events. Anti-CD-20 inhibitors and TNF-alpha inhibitors were associated with opportunistic infections. Transient increase in HIV viral load was noted with use of some agents such as TNF-alpha inhibitors. The quality of evidence is low, restricted to case reports and retrospective reviews. However, the safety profile of biologics observed in these patients with HIV was overall favorable.
- Subjects
HIV infection complications; BIOTHERAPY; HIV-positive persons; ONLINE information services; DRUG efficacy; SAFETY; MEDICAL information storage &; retrieval systems; INFLAMMATION; SYSTEMATIC reviews; MONOCLONAL antibodies; TUMOR necrosis factors; MEDLINE; DRUG side effects; AIDS-related opportunistic infections
- Publication
AIDS Patient Care & STDs, 2023, Vol 37, Issue 5, p215
- ISSN
1087-2914
- Publication type
Article
- DOI
10.1089/apc.2022.0197