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- Title
Primary Burkitt's lymphoma of the thyroid without Epstein-Barr virus infection: A case report and literature review.
- Authors
LIYING ZHANG; LANXIANG GAO; GUANG LIU; LUPING WANG; CHUNWEI XU; LIN LI; YUWANG TIAN; HUIRU FENG; ZHE GUO
- Abstract
Primary thyroid lymphomas are rare, and the majority are B-cell lymphoma. Primary Burkitt's lymphoma (BL) of the thyroid is much less common than the other types of lymphoma. The current study presents the case of an eight-year-old male with a mass in the right lobe of the thyroid, which was detected by B-ultrasound. The patient was diagnosed with BL by immunohistochemistry, fluorescence in situ hybridization analysis of MYC (8q24) and immunoglobulin rearrangement assays. Furthermore, subsequent positron emission tomography-computed tomography scans revealed no abnormal metabolites in the left lobe of the thyroid or in other parts of the body following surgery. The patient underwent alternate R-B-NHL-BFM-90-A and R-B-NHL-BFM-90-B treatment for four cycles each following the thyroidectomy. The patient is well and remains free of disease recurrence following almost four years follow-up. The present study discusses this rare case of primary BL of the thyroid and presents a review of the literature. This case report provides evidence that the immediate diagnosis and treatment of primary Burkitt's lymphoma of the thyroid is likely to improve patient outcome.
- Subjects
BURKITT'S lymphoma; LYMPHOMA treatment; EPSTEIN-Barr virus diseases; ULTRASONIC imaging of cancer; IMMUNOHISTOCHEMISTRY; IN situ hybridization; PATIENTS
- Publication
Oncology Letters, 2014, Vol 7, Issue 5, p1519
- ISSN
1792-1074
- Publication type
Case Study
- DOI
10.3892/ol.2014.1941