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- Title
Recombinant Human Tumour Necrosis Factor β (Lymphotoxin) Lacks Chemotactic Activity for Human Peripheral Blood Neutrophils, Monocytes, and T Cells.
- Authors
Mrowietz, U.; Ternowitz, T.; Schröder, J.-M.; Christophers, E.
- Abstract
Human recombinant tumour necrosis factor β (rhuTNFβ)/lymphotoxin was tested for human neutrophil granulocyte (PMN), monocytes (MO), and T-cell chemotactic activity by means of a modified Boyden chamber system. Over a wide range of concentrations (10-7-10-14M) rhuTNFβ showed no chemotactic activity for PMN, MO, or T cells. In contrast, strong chemotactic migration was elicited in PMN and MO with the tripeptide N-formyl-methionyl-leucylphenylalanine (FMLP) and in T cells when complement split product C5a and leukotriene B4 (LTB>4) were used as chemotaxins. The results of this study indicate that rhuTNFβ/lymphotoxin is not a chemotaxin for human PMN, MO, or T lymphocytes in vitro.
- Subjects
TUMOR necrosis factors; LYMPHOCYTES; T cells; TUMORS; CYTOKINES; GLYCOPROTEINS
- Publication
Scandinavian Journal of Immunology, 1989, Vol 30, Issue 3, p373
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1989.tb01224.x