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- Title
The genetic script of metastasis.
- Authors
Jinesh, Goodwin G.; Brohl, Andrew S.
- Abstract
Metastasis is a pivotal event that changes the course of cancers from benign and treatable to malignant and difficult to treat, resulting in the demise of patients. Understanding the genetic control of metastasis is thus crucial to develop efficient and sustainable targeted therapies. Here we discuss the alterations in epigenetic mechanisms, transcription, chromosomal instability, chromosome imprinting, non‐coding RNAs, coding RNAs, mutant RNAs, enhancers, G‐quadruplexes, and copy number variation to dissect the genetic control of metastasis. We conclude that the genetic control of metastasis is predominantly executed through epithelial to mesenchymal transition and evasion of cell death. We discuss how genetic regulatory mechanisms can be harnessed for therapeutic purposes to achieve sustainable control over cancer metastasis.
- Subjects
QUADRUPLEX nucleic acids; METASTASIS; NON-coding RNA; CELL death; SCRIPTS
- Publication
Biological Reviews, 2020, Vol 95, Issue 1, p244
- ISSN
1464-7931
- Publication type
Article
- DOI
10.1111/brv.12562