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- Title
Cu‐Catalyzed Cross‐Coupling Reactions of Enamines and Terminal Alkynes: Access of Propargylamines as Neurodegenerative Disorder Agents.
- Authors
Mohan, Lakavathu; Lee, Ji Eun; Srinivasarao, Mande; Cutright, Alexander J.; Raju, Selvam; Stokes, Sean. L.; Emerson, Joseph. P.; Kim, Jae Hong
- Abstract
Reactions between enamine analogues and terminal alkynes were explored. Copper(I) complex of 1,10‐phenanthroline catalyzed these reactions to generate a diastereoselective propargylamines via C−C bond formation. In the presence of Zn2+, the chiral propargylamines converted into the β‐allenoates with an excellent yield and enantioselectivity achieved up to 99 %. Models of synthesized propargylamines were used for molecular docking and dynamic simulations, which indicate that this class of molecules shows promise for anti‐neurodegenerative activity.
- Subjects
PROPARGYLAMINES; NEURODEGENERATION; ENAMINES; ALKYNES; MOLECULAR docking
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 10, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300375