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- Title
Effective Magnesium‐catalyzed Hydroboration of Nitriles and Imines.
- Authors
Seok, Ji Eun; Kim, Hyun Tae; Kim, Jaeho; Lee, Ji Hye; Jaladi, Ashok Kumar; Hwang, Hyonseok; An, Duk Keun
- Abstract
The reduction of stable functional groups such as nitriles into amines under eco‐friendly conditions is an important conversion process in organic synthesis. The effective hydroboration of nitriles and imines with pinacolborane using ethoxymagnesium chloride was demonstrated under solvent‐free conditions at room temperature. A variety of nitriles and imines were converted into the corresponding amines in excellent yields. In addition, the chemoselective hydroboration of nitriles over alkenes and alkynes was reported in good yields. Furthermore, a suitable reaction mechanism for nitrile hydroboration was proposed based on density functional theory calculations.
- Subjects
HYDROBORATION; IMINES; DENSITY functional theory; ORGANIC synthesis
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 10, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202200405