We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Homocysteine in Inflammatory Bowel Disease: A Risk Factor for Thromboembolic Complications?
- Authors
Oldenburg, Bas; Fijnheer, Rob; Van der Griend, René; VanBerge-Henegouwen, Gerard P.; Koningsberger, Jacob C.
- Abstract
OBJECTIVE: Patients with inflammatory bowel disease (IBD) are at increased risk for thromboembolic events. Hyperho-mocysteinemia, which is an established risk factor for arterial as well as venous thrombosis, may be more prevalent in IBD because of vitamin deficiencies. METHODS: In this retrospective study, we studied the concentrations of total homocysteine (tHcy). cobalamin, folate, and pyridoxine in 231 consecutive patients with IBD. of whom 16 patients had a history of venous thrombosis, and nine a history of arterial thrombosis. Age- and gender-matched healthy volunteers served as controls (n = 102). RESULTS: Homocysteine concentrations in patients were higher (12.3 µmol/L [range 4.6-51.31 <em>vs</em> 11.1 µmol/L [range 3.9-27.6]. <em>p</em> = 0.001) and hyperhomocysteinemia tended to be more prevalent in patients than in the controls (11.1% <em>vs</em> 5%, <em>p</em> = 0.07). Folate, cobalamin, creatinine. and pyridoxine concentrations were correlated with tHcy. Folate deficiency was infrequently encountered in IBD patients (4.3%). The tHcy concentration in patients with a history of venous or arterial thrombosis was not higher than in patients without a history of thrombosis (12.7 µmol/L [range 4.6-40.1] and 15.2 µ mol/L (range 10.5-26.8) <em>vs</em> 12.3 /µ mol/L [range 10.5-26.8], not significant). Hyperhomocysteinemia was found in 18.8% of the patients with venous thrombosis. 11.1 % of the patients with arterial thrombosis, and 10.5% of the patients without thrombosis (not significant). CONCLUSIONS: Hyperhomocysteinemia is a common phenomenon in IBD and correlates with serum folate. cobalamin. creatinine, and pyridoxine concentrations. No correlation between tHcy and a history of venous or arterial thromhoembolic complications is found. Hyperhomocysteinemia does not seem to be a major contributory factor in the development of venous or arterial thrombosis in IBD patients.
- Subjects
INFLAMMATORY bowel diseases; THROMBOEMBOLISM; VENOUS thrombosis; HOMOCYSTEINE; CREATINE; VITAMIN B12; VITAMIN B6
- Publication
American Journal of Gastroenterology (Springer Nature), 2000, Vol 95, Issue 10, p2825
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2000.03193.x