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- Title
Evaluation of Short-Chain Fatty Acid Enemas: Treatment of Radiation Proctitis.
- Authors
Al-Sabbagh, Radwan; Sinicrope, Frank A.; Sellin, Joseph H.; Yu Shen; Roubein, Leor
- Abstract
Background: Radiation proctitis is a common complication of abdominal and pelvic radiotherapy: unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colitides. We sought to determine whether SCFA enemas have a role in the treatment of radiation proctitis. Methods: Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis. Results: Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters. Conclusion: SCFA are a promising therapeutic option in radiation proctitis.
- Subjects
CLINICAL trials; RADIOTHERAPY; ABDOMINAL radiography; PELVIC radiography; FATTY acids; ENEMA
- Publication
American Journal of Gastroenterology (Springer Nature), 1996, Vol 91, Issue 9, p1814
- ISSN
0002-9270
- Publication type
Article