We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Multicentric Primary Adenocarcinomas of the Midgut: The First Case Report.
- Authors
Liu, Katherine J. M.; Nadimpalli, Venkat; Atten, Mary Jo; Chang, Helena R.; Finkelstein, Sydney D.; Mak, Ken; Attar, Bashar M.; Donahue, Philip E.
- Abstract
Multicentric adenocarcinomas of the midgut have not been described; even multiple adenocarcinomas limited to the small intestine are extremely uncommon, with only 14 cases reported in the literature. We report a case of multicentric synchronous involvement of the entire midgut with adenocarcinoma in a 52-yr-old Polish woman who had more than 30 lesions extending from duodenum to mid-transverse colon. There was no family history of cancer. Preoperative evaluation and intraoperative exploration were negative for primary malignancy of the lungs, breasts, ovaries, pancreas, and other parts of the gastrointestinal tract. Results of histopathological examination, immunohistochemical staining, and <em>ras</em> mutational analysis of the lesions uniformly support the diagnosis of multicentric poorly differentiated adenocarcinoma. The cause for this unusual presentation is unknown, although sporadic genetic alteration(s) of oncogene(s) might have been the precipitating event.
- Subjects
ADENOCARCINOMA; SMALL intestine; COLON cancer; CANCER; PANCREAS; OVARIES; LUNGS; BREAST
- Publication
American Journal of Gastroenterology (Springer Nature), 1996, Vol 91, Issue 6, p1239
- ISSN
0002-9270
- Publication type
Article