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- Title
Impact of molecular status on clinical management in children with histiocytosis treated according to POL HISTIO project.
- Authors
Raciborska, Anna; Małas, Zofia; Tysarowski, Andrzej; Seliga, Katarzyna; Machnik, Katarzyna; Wecławek-Tompol, Jadwiga; Derwich, Katarzyna; Rurańska, Iwona; Muszyńska-Rosłan, Katarzyna; Michalak, Elżbieta; Badowska, Wanda; Karolczyk, Grażyna; Chaber, Radosław; Drabko, Katarzyna; Rodriguez-Galindo, Carlos
- Abstract
The article focuses on rare histiocytic disorders characterized by abnormal cell proliferation linked to the RAS/MAPK signaling pathway. It introduces the classification of histiocytosis into five groups and highlights Langerhans cell histiocytosis (LCH) in children, with variations in severity. It emphasizes the role of molecular status, particularly BRAF mutations, in diagnosing and managing these disorders.
- Subjects
LANGERHANS-cell histiocytosis; HISTIOCYTOSIS; ERDHEIM-Chester disease; MEDICAL ethics; MITOGEN-activated protein kinases; NON-langerhans-cell histiocytosis
- Publication
Acta Haematologica Polonica, 2023, Vol 54, Issue 5, p313
- ISSN
0001-5814
- Publication type
Article
- DOI
10.5603/ahp.95452