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- Title
Antimicrobial mechanism of lantibiotics.
- Authors
Islam, Mohammad R.; Nagao, Jun-ichi; Zendo, Takeshi; Sonomoto, Kenji
- Abstract
Lantibiotics are ribosomally synthesized antimicrobial peptides that commonly target the cell wall precursor lipid II during their antimicrobial mechanism and exert their inhibitory activity by (i) inhibition of cell wall biosynthesis, and (ii) stable pore formation in the target membrane. Type-A(I) (i.e. nisin) and twocomponent (i.e. lacticin 3147) lantibiotics initially interact with lipid II to stabilize the complex, which then proceeds to inhibit cell wall biosynthesis and pore formation. Type-A(II) (i.e. nukacin ISK-1) and type-B (i.e. mersacidin) lantibiotics also use lipid II as a docking molecule, but can only inhibit cell wall biosynthesis without forming pores. In the present paper, we review the antimicrobial mechanism of different types of lantibiotics, their current progress and future prospect.
- Subjects
LANTIBIOTICS; ANTI-infective agents; BIOSYNTHESIS; BACTERIAL cell walls; RIBOSOME structure
- Publication
Biochemical Society Transactions, 2012, Vol 40, Issue 6, p1528
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20120190