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- Title
Pathophysiologic Role of Histamine: Evidence Clarified by Histidine Decarboxylase Gene Knockout Mice.
- Authors
Ohtsu, Hiroshi
- Abstract
The role of histamine in various murine disease models has been clarified using histidine decarboxylase gene knockout mice. The mice were generated using conventional gene-targeting methods. Studies, including ours, using knockout mice have shown that the activity of histamine is not limited to allergic, peptic and neurologic functions as in the old paradigm, but extends to other processes related to wound healing, circulatory disease, immunology, oncology and infectious disease. The recent observation of the activity of newly cloned histamine receptors and a pathophysiologic effect of histamine has dramatically expanded our understanding of the scope of histamine function. Copyright © 2012 S. Karger AG, Basel
- Subjects
HISTIDINE decarboxylase; HISTAMINE receptors; GRANULOCYTE-macrophage colony-stimulating factor; RESPIRATORY allergy; ANTIHISTAMINES; MOLECULAR immune response
- Publication
International Archives of Allergy & Immunology, 2012, Vol 158, p2
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000337735