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- Title
A comparison study between Candida parapsilosis sepsis and Candida albicans sepsis in preterm infants.
- Authors
Shaodong Hua; Jieting Huang; Zhixin Wu; Zhichun Fen
- Abstract
In this study, we aimed to investigate the clinical characteristics of Candida parapsilosis sepsis in preterm infants. In this retrospective analysis of the clinical data of 11 cases of Candida parapsilosis sepsis and 13 cases of C. albicans sepsis, the two groups were compared for research using one-way analysis of variance (one-way ANOVA), Χ₂ test, and non-conditional logistic regression analysis. Compared to the C. albicans sepsis group, the C. parapsilosis group demonstrated a significantly lower birth weight (1331.8±252.41 vs. 1721.2±589.08) and significantly longer hospital stay (69.909±20.782 vs. 38.385±19.923) (t′/t = 2.160, -3.787; p=0.045, 0.01, respectively); the incidences of retinopathy of prematurity (ROP) (72.7% vs. 30.8%), tienam administration (72.7% vs. 23.1%), pneumothorax, and thoracic closed drainage (27.3% vs. 0) were higher (Z2=4.196, 5.916, 4.052; p=0.041, 0.015, 0.044, respectively). Logistic regression analysis indicated only hospital stay and tienam administration in the regression equation (~2=18.008, p=0.000). Compared with C. albicans sepsis, an average length hospital stay and administration of tienam are the high-risk factors for C. parapsilosis sepsis. With regard to the other predisposing factors of preterm infant fungal sepsis, there were no differences between the two groups.
- Subjects
SEPSIS; CANDIDA albicans; SEPTICEMIA in children; PREMATURE infant diseases; ANALYSIS of variance; COMPARATIVE studies; CLINICAL trials; DISEASE risk factors
- Publication
Turkish Journal of Pediatrics, 2012, Vol 54, Issue 5, p502
- ISSN
0041-4301
- Publication type
Article