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- Title
Anticancer Activity of 2-Amino-substituted-1,4-naphthoquinone Derivatives in Ovarian Cancer Cells.
- Authors
Shin, Sujeong; Lee, Haneul; Jeon, Cheolmin; Preya, Umma Hafsa; Choi, Jung‐Hye; Park, Jeong Ho
- Abstract
2-Amino-substituted-1,4-naphthoquinone derivatives ( 10- 17) were synthesized from coupling reaction between 1,4-dihydroxynaphthalene and amines in the presence of catalyst CeCl3.7H2O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC50 < 10 μM) on all three ovarian cancer cells.
- Subjects
NAPHTHOQUINONE; ANTINEOPLASTIC agents; OVARIAN cancer; CANCER cells; ANTINEOPLASTIC antibiotics
- Publication
Bulletin of the Korean Chemical Society, 2017, Vol 38, Issue 12, p1411
- ISSN
0253-2964
- Publication type
Article
- DOI
10.1002/bkcs.11315