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- Title
In memoriam: Bernard W. Agranoff (1926–2022).
- Authors
Fisher, Stephen K.; Akil, Huda
- Abstract
Bernie's wife, the late Ricky Agranoff, was a warm and caring person who shared Bernie's interest in food. Along with Amiya Hajra, he identified a novel lipid intermediate-acyl dihydroxyacetone phosphate, which provided an alternative biosynthetic pathway for the synthesis of phosphatidate and the synthesis of ether lipids in the brain (Agranoff & Hajra, [8]). In addition to inositol containing lipids, Bernie also had a long-standing interest in inositol itself, having worked on its biosynthesis with Harry Eagle while at NIH. Bernie also was one of the first to identify the formation of inositol trisphosphate following receptor-mediated activation of phosphatidylinositol 4,5-bisphosphate breakdown, this time in platelets (his own!), using a high-voltage electrophoretic technique pioneered in his laboratory several years earlier (Agranoff et al., [10]).
- Subjects
BIOCHEMISTRY; MUSCARINIC receptors; BEHAVIORAL neuroscience; ETHER lipids; MNEMONICS
- Publication
Journal of Neurochemistry, 2023, Vol 164, Issue 6, p875
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/jnc.15749