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- Title
Intrathecal oligoclonal bands synthesis in multiple sclerosis: is it always a prognostic factor?
- Authors
Frau, Jessica; Villar, Luisa Maria; Sardu, Claudia; Secci, Maria Antonietta; Schirru, Lucia; Ferraro, Diana; Coghe, Giancarlo; Lorefice, Lorena; Fenu, Giuseppe; Bedin, Roberta; Sola, Patrizia; Marrosu, Maria Giovanna; Cocco, Eleonora
- Abstract
Background: Oligoclonal IgM (OCMB) and IgG (OCGB) bands were found to be associated with poor multiple sclerosis (MS) prognosis.Objective: We aimed to evaluate the prognostic value of OCMB/OCGB in a cohort of Sardinian MS patients.Materials and methods: We recruited patients from the University of Cagliari. They underwent lumbar puncture for diagnostic purposes. Demographic and the following clinical data were recorded: clinical course; time to reach EDSS 3 and 6; EDSS at last follow-up; and MS treatments. The influence of gender, clinical course, age at onset, treatments, and OCGB/OCMB on reaching EDSS 3 was analysed using Cox regression. Kaplan–Meier curves were used to study the time to reach EDSS 3 considering OCMB/OCGB and therapies.Results: The enrolled number of subjects was 503. The variables influencing the achievement of EDSS 3.0 were: male gender (<italic>p</italic> = 0.005); progressive course (<italic>p</italic> = 0.001); age at onset (<italic>p</italic> < 0.001); and disease-modifying drugs (<italic>p</italic> < 0.001). The OCGB/OCMB status was not significant. Kaplan–Meier analysis showed no difference in time to reach EDSS 3 for patients with and without OCGB or OCMB in both treated and non-treated groups.Conclusion: Our study did not confirm the poor prognostic value of OCMB/OCGB. These results may be influenced by the peculiar genetic background associated with the risk of MS in Sardinians.
- Subjects
MULTIPLE sclerosis; OLIGOCLONAL bands; IMMUNOGLOBULIN M; IMMUNOGLOBULIN G; GENETICS; PROGNOSIS
- Publication
Journal of Neurology, 2018, Vol 265, Issue 2, p424
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-017-8716-4