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- Title
Induction of immune responses in ducks with a DNA vaccine encoding duck plague virus glycoprotein C.
- Authors
Bei Lian; Anchun Cheng; Mingshu Wang; Dekang Zhu; Qihui Luo; Renyong Jia; Fei Liu; Xinfeng Han; Xiaoyue Chen
- Abstract
Background: A DNA vaccine expressing glycoprotein C (gC) of duck plague virus (DPV) was evaluated for inducing immunity in ducks. The plasmid encoding gC of DPV was administered via intramuscular (IM) injection and gene gun bombardment. Results: After immunization by both routes virus-specific serum antibody and T-cell responses developed. Vaccination of ducks by IM injection induced a stronger humoral, but weaker cell-mediated immune response. In contrast, a better cell-mediated immune response was achieved by using a gene gun to deliver DNA-coated gold beads to the epidermis with as little as 6 μg of DNA. Conclusions: This demonstrated that both routes of DNA inoculation can be used for eliciting virus-specific immune responses. Although DNA vaccine containing DPV gC is effective in both intramuscular injection and gene gun bombardment, the latter could induce significantly higher cell-mediated responses against DPV.
- Subjects
DUCK plague virus; DNA vaccines; GLYCOPROTEINS; IMMUNE response; T cell receptors
- Publication
Virology Journal, 2011, Vol 8, Issue 1, p214
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/1743-422X-8-214