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- Title
New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity.
- Authors
Barbuceanu, Stefania F.; Almajan, Gabriela L.; Saramet, Ioana; Draghici, Constantin; Socoteanu, Radu; Barbuceanu, Florica
- Abstract
Alkylation of the 5-(4-[(4-bromophenyl)sulfonyl]phenyl)-4-(3/4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones 3a,b with various alkylation agents, i.e., ethyl bromide, phenacyl bromide and ethyl chloroacetate, afforded the S-substituted 1,2,4-triazoles 4-6a,b. The structures of these new compounds were elucidated by elemental analysis and IR, UV, 1H-NMR, 13C- -NMR and MS spectroscopy. The newly synthesized products were tested for their antibacterial effects.
- Subjects
ALKYLATION; TRIAZOLES; SULFONES; ETHYL bromide; ANTIBACTERIAL agents
- Publication
Journal of the Serbian Chemical Society, 2009, Vol 74, Issue 10, p1041
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC0910041B