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OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.
Published in:
2015
By:
- Johnson, Philip L;
- Federici, Lauren M;
- Fitz, Stephanie D;
- Renger, John J;
- Shireman, Brock;
- Winrow, Christopher J;
- Bonaventure, Pascal;
- Shekhar, Anantha
Publication type:
journal article
OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.
Published in:
Depression & Anxiety (1091-4269), 2015, v. 32, n. 9, p. 671, doi. 10.1002/da.22403
By:
- Johnson, Philip L.;
- Federici, Lauren M.;
- Fitz, Stephanie D.;
- Renger, John J.;
- Shireman, Brock;
- Winrow, Christopher J.;
- Bonaventure, Pascal;
- Shekhar, Anantha
Publication type:
Article
Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors.
Published in:
Pharmacology Research & Perspectives, 2019, v. 7, n. 1, p. 1, doi. 10.1002/prp2.466
By:
- Wang, Lien;
- Lee, Grace;
- Shih, Amy;
- Kuei, Chester;
- Nepomuceno, Diane;
- Wennerholm, Michelle;
- Fan, Frances;
- Wu, Jiejun;
- Bonaventure, Pascal;
- Lovenberg, Timothy W.;
- Liu, Changlu
Publication type:
Article
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.
Published in:
Translational Psychiatry, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41398-020-00937-9
By:
- Salvadore, Giacomo;
- Bonaventure, Pascal;
- Shekhar, Anantha;
- Johnson, Philip L.;
- Lord, Brian;
- Shireman, Brock T.;
- Lebold, Terry P.;
- Nepomuceno, Diane;
- Dugovic, Christine;
- Brooks, Sander;
- Zuiker, Rob;
- Bleys, Cathy;
- Tatikola, Kanaka;
- Remmerie, Bart;
- Jacobs, Gabriel E.;
- Schruers, Koen;
- Moyer, John;
- Nash, Abigail;
- Van Nueten, Luc G. M.;
- Drevets, Wayne C.
Publication type:
Article
Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7.
Published in:
Annals of the New York Academy of Sciences, 2009, v. 1160, p. 31, doi. 10.1111/j.1749-6632.2008.03790.x
By:
- Liu, Changlu;
- Kuei, Chester;
- Sutton, Steven;
- Shelton, Jonathan;
- Zhu, Jessica;
- Nepomuceno, Diane;
- Hossain, Mohammed Akhter;
- Wade, John D.;
- Bathgate, Ross A. D.;
- Bonaventure, Pascal;
- Lovenberg, Timothy
Publication type:
Article
Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System.
Published in:
Annals of the New York Academy of Sciences, 2009, v. 1160, p. 242, doi. 10.1111/j.1749-6632.2008.03812.x
By:
- Sutton, Steven W.;
- Shelton, Jonathan;
- Smith, Craig;
- Williams, John;
- Yun, Sujin;
- Motley, Timothy;
- Kuei, Chester;
- Bonaventure, Pascal;
- Gundlach, Andrew;
- Liu, Changlu;
- Lovenberg, Timothy
Publication type:
Article
Relaxin Family Peptides and Receptors in Mammalian Brain.
Published in:
Annals of the New York Academy of Sciences, 2009, v. 1160, p. 226, doi. 10.1111/j.1749-6632.2009.03956.x
By:
- Gundlach, Andrew L.;
- Ma, Sherie;
- Sang, Qian;
- Shen, Pei‐Juan;
- Piccenna, Loretta;
- Sedaghat, Katayoun;
- Smith, Craig M.;
- Bathgate, Ross A. D.;
- Lawrence, Andrew J.;
- Tregear, Geoffrey W.;
- Wade, John D.;
- Finkelstein, David I.;
- Bonaventure, Pascal;
- Liu, Changlu;
- Lovenberg, Timothy W.;
- Sutton, Steve W.
Publication type:
Article
Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope.
Published in:
PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112068
By:
- Berdyyeva, Tamara;
- Otte, Stephani;
- Aluisio, Leah;
- Ziv, Yaniv;
- Burns, Laurie D.;
- Dugovic, Christine;
- Yun, Sujin;
- Ghosh, Kunal K.;
- Schnitzer, Mark J.;
- Lovenberg, Timothy;
- Bonaventure, Pascal
Publication type:
Article
In Vitro Pharmacological Characterization of RXFP3 Allosterism: An Example of Probe Dependency.
Published in:
PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0030792
By:
- Alvarez-Jaimes, Lily;
- Sutton, Steven W.;
- Nepomuceno, Diane;
- Motley, S. Timothy;
- Cik, Miroslav;
- Stocking, Emily;
- Shoblock, James;
- Bonaventure, Pascal
Publication type:
Article
Pharmacological Blockade of Serotonin 5-HT7 Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission.
Published in:
PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0020210
By:
- Bonaventure, Pascal;
- Aluisio, Leah;
- Shoblock, James;
- Boggs, Jamin D.;
- Fraser, Ian C.;
- Lord, Brian;
- Lovenberg, Timothy W.;
- Galici, Ruggero
Publication type:
Article
Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.
Published in:
Frontiers in Behavioral Neuroscience, 2015, v. 8, p. 1, doi. 10.3389/fnbeh.2014.00453
By:
- Shelton, Jonathan;
- Sujin Yun;
- Olson, Susan Losee;
- Turek, Fred;
- Bonaventure, Pascal;
- Dvorak, Curt;
- Lovenberg, Timothy;
- Dugovic, Christine
Publication type:
Article
Characterization of tritiated JNJ‐GluN2B‐5 (3‐[3H] 1‐(azetidin‐1‐yl)‐2‐(6‐(4‐fluoro‐3‐methyl‐phenyl)pyrrolo[3,2‐b]pyridin‐1‐yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors
Published in:
Journal of Neurochemistry, 2024, v. 168, n. 9, p. 2654, doi. 10.1111/jnc.16129
By:
- Schoellerman, Jeffrey;
- Lord, Brian;
- Bhattacharya, Anindya;
- Stenne, Brice;
- Wall, Jessica L.;
- Rech, Jason;
- Letavic, Michael;
- Bonaventure, Pascal;
- Balana, Bartosz
Publication type:
Article
Recent Progress in Relaxin-3--Related Research.
Published in:
Annals of the New York Academy of Sciences, 2005, v. 1041, n. 1, p. 47, doi. 10.1196/annals.1282.009
By:
- LIU, CHANGLU;
- BONAVENTURE, PASCAL;
- SUTTON, STEVEN W.;
- CHEN, JINGCAI;
- KUEI, CHESTER;
- NEPOMUCENO, DIANE;
- LOVENBERG, TIMOTHY W.
Publication type:
Article
Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids.
Published in:
PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0240991
By:
- Woodruff, Grace;
- Phillips, Naomi;
- Carromeu, Cassiano;
- Guicherit, Oivin;
- White, Alistair;
- Johnson, McCay;
- Zanella, Fabian;
- Anson, Blake;
- Lovenberg, Timothy;
- Bonaventure, Pascal;
- Harrington, Anthony W.
Publication type:
Article
Mapping of serotonin 5-HT4 receptor mRNA and ligand binding sites in the post-mortem human brain.
Published in:
Synapse, 2000, v. 36, n. 1, p. 35, doi. 10.1002/(SICI)1098-2396(200004)36:1<35::AID-SYN4>3.0.CO;2-Y
By:
- Bonaventure, Pascal;
- Hall, Håkan;
- Gommeren, Walter;
- Cras, Patrick;
- Langlois, Xavier;
- Jurzak, Mirek;
- Leysen, Josée E.
Publication type:
Article
Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice.
Published in:
Frontiers in Neuroscience, 2016, p. 1, doi. 10.3389/fnins.2016.00053
By:
- Berdyyeva, Tamara K.;
- Frady, E. Paxon;
- Nassi, Jonathan J.;
- Aluisio, Leah;
- Cherkas, Yauheniya;
- Otte, Stephani;
- Wyatt, Ryan M.;
- Dugovic, Christine;
- Ghosh, Kunal K.;
- Schnitzer, Mark J.;
- Lovenberg, Timothy;
- Bonaventure, Pascal
Publication type:
Article
Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex.
Published in:
Frontiers in Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fnins.2014.00107
By:
- Aluisio, Leah;
- Fraser, Ian;
- Berdyyeva, Tamara;
- Tryputsen, Volha;
- Shireman, Brock T.;
- Shoblock, James;
- Lovenberg, Timothy;
- Dugovic, Christine;
- Bonaventure, Pascal
Publication type:
Article
Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.
Published in:
Frontiers in Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fnins.2014.00028
By:
- Dugovic, Christine;
- Shelton, Jonathan E.;
- Sujin Yun;
- Bonaventure, Pascal;
- Shireman, Brock T.;
- Lovenberg, Timothy W.
Publication type:
Article
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.
Published in:
Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05308-x
By:
- Prischich, Davia;
- Sortino, Rosalba;
- Gomila-Juaneda, Alexandre;
- Matera, Carlo;
- Guardiola, Salvador;
- Nepomuceno, Diane;
- Varese, Monica;
- Bonaventure, Pascal;
- de Lecea, Luis;
- Giralt, Ernest;
- Gorostiza, Pau
Publication type:
Article
Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement.
Published in:
Psychopharmacology, 2011, v. 215, n. 1, p. 191, doi. 10.1007/s00213-010-2127-x
By:
- Shoblock, James;
- Welty, Natalie;
- Aluisio, Leah;
- Fraser, Ian;
- Motley, S.;
- Morton, Kirsten;
- Palmer, James;
- Bonaventure, Pascal;
- Carruthers, Nicholas;
- Lovenberg, Timothy;
- Boggs, Jamin;
- Galici, Ruggero
Publication type:
Article
JNJ-39220675, a novel selective histamine H receptor antagonist, reduces the abuse-related effects of alcohol in rats.
Published in:
Psychopharmacology, 2011, v. 214, n. 4, p. 829, doi. 10.1007/s00213-010-2092-4
By:
- Galici, Ruggero;
- Rezvani, Amir;
- Aluisio, Leah;
- Lord, Brian;
- Levin, Edward;
- Fraser, Ian;
- Boggs, Jamin;
- Welty, Natalie;
- Shoblock, James;
- Motley, S.;
- Letavic, Michael;
- Carruthers, Nicholas;
- Dugovic, Christine;
- Lovenberg, Timothy;
- Bonaventure, Pascal
Publication type:
Article
In vitro and in vivo characterization of JNJ-31020028 ( N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor
Published in:
Psychopharmacology, 2010, v. 208, n. 2, p. 265, doi. 10.1007/s00213-009-1726-x
By:
- Shoblock, James R.;
- Welty, Natalie;
- Nepomuceno, Diane;
- Lord, Brian;
- Aluisio, Leah;
- Fraser, Ian;
- Motley, S. Timothy;
- Sutton, Steve W.;
- Morton, Kirsten;
- Galici, Ruggero;
- Atack, John R.;
- Dvorak, Lisa;
- Swanson, Devin M.;
- Carruthers, Nicholas I.;
- Dvorak, Curt;
- Lovenberg, Timothy W.;
- Bonaventure, Pascal
Publication type:
Article
PET Brain Imaging of Neuropeptide Y2 Receptors Using N-11C-Methyl-JNJ-31020028 in Pigs.
Published in:
Journal of Nuclear Medicine, 2014, v. 55, n. 4, p. 635, doi. 10.2967/jnumed.113.125351
By:
- Winterdahl, Michael;
- Audrain, Hélène;
- Landau, Anne M.;
- Smith, Donald F.;
- Bonaventure, Pascal;
- Shoblock, James R.;
- Carruthers, Nicholas;
- Swanson, Devin;
- Bender, Dirk
Publication type:
Article
Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex.
Published in:
Journal of Neurochemistry, 2010, v. 115, n. 2, p. 475, doi. 10.1111/j.1471-4159.2010.06947.x
By:
- Wei Si;
- Aluisio, Leah;
- Okamura, Naoe;
- Clark, Stewart D.;
- Fraser, Ian;
- Sutton, Steven W.;
- Bonaventure, Pascal;
- Reinscheid, Rainer K.
Publication type:
Article
In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist.
Published in:
Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00273
By:
- Shoblock, James R.;
- Welty, Natalie;
- Fraser, Ian;
- Wyatt, Ryan;
- Lord, Brian;
- Lovenberg, Timothy;
- Liu, Changlu;
- Bonaventure, Pascal
Publication type:
Article
Identification and characterization of select oxysterols as ligands for GPR17.
Published in:
British Journal of Pharmacology, 2023, v. 180, n. 4, p. 401, doi. 10.1111/bph.15969
By:
- Harrington, Anthony W.;
- Liu, Changlu;
- Phillips, Naomi;
- Nepomuceno, Diane;
- Kuei, Chester;
- Chang, Joseph;
- Chen, Weixuan;
- Sutton, Steven W.;
- O'Malley, Daniel;
- Pham, Ly;
- Yao, Xiang;
- Sun, Siquan;
- Bonaventure, Pascal
Publication type:
Article
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.
Published in:
Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00357
By:
- Bonaventure, Pascal;
- Dugovic, Christine;
- Shireman, Brock;
- Preville, Cathy;
- Yun, Sujin;
- Lord, Brian;
- Nepomuceno, Diane;
- Wennerholm, Michelle;
- Lovenberg, Timothy;
- Carruthers, Nicolas;
- Fitz, Stephanie D.;
- Shekhar, Anantha;
- John, Philip L.
Publication type:
Article
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.
Published in:
British Journal of Pharmacology, 2013, v. 170, n. 3, p. 624, doi. 10.1111/bph.12314
By:
- Bhattacharya, Anindya;
- Wang, Qi;
- Ao, Hong;
- Shoblock, James R;
- Lord, Brian;
- Aluisio, Leah;
- Fraser, Ian;
- Nepomuceno, Diane;
- Neff, Robert A;
- Welty, Natalie;
- Lovenberg, Timothy W;
- Bonaventure, Pascal;
- Wickenden, Alan D;
- Letavic, Michael A
Publication type:
Article
G-Protein-Coupled Receptor (GPCR)-142 Does Not Contribute to Relaxin-3 Binding in the Mouse Brain: Further Support that Relaxin-3 Is the Physiological Ligand for GPCR135.
Published in:
Neuroendocrinology, 2005, v. 82, n. 3/4, p. 139, doi. 10.1159/000091267
By:
- Sutton, Steven W.;
- Bonaventure, Pascal;
- Kuei, Chester;
- Nepomuceno, Diane;
- Wu Jiejun;
- Zhu, Jessica;
- Lovenberg, Timothy W.;
- Changlu Liu
Publication type:
Article
Distribution of G-Protein-Coupled Receptor (GPCR)135 Binding Sites and Receptor mRNA in the Rat Brain Suggests a Role for Relaxin-3 in Neuroendocrine and Sensory Processing.
Published in:
Neuroendocrinology, 2004, v. 80, n. 5, p. 298, doi. 10.1159/000083656
By:
- Sutton, Steven W.;
- Bonaventure, Pascal;
- Kuei, Chester;
- Roland, Barbara;
- Jingcai Chen;
- Nepomuceno, Diane;
- Lovenberg, Timothy W.;
- Changlu Liu
Publication type:
Article
GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.
Published in:
Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00281
By:
- Wang, Lien;
- Lee, Grace;
- Kuei, Chester;
- Yao, Xiang;
- Harrington, Anthony;
- Bonaventure, Pascal;
- Lovenberg, Timothy W.;
- Liu, Changlu
Publication type:
Article
In vivo Calcium Imaging Reveals That Cortisol Treatment Reduces the Number of Place Cells in Thy1-GCaMP6f Transgenic Mice.
Published in:
Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00176
By:
- Indersmitten, Tim;
- Schachter, Michael J.;
- Young, Stephanie;
- Welty, Natalie;
- Otte, Stephani;
- Nassi, Jonathan J.;
- Lovenberg, Timothy;
- Bonaventure, Pascal;
- Wyatt, Ryan M.
Publication type:
Article
Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.
Published in:
Frontiers in Behavioral Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnbeh.2017.00083
By:
- Sujin Yun;
- Wennerholm, Michelle;
- Shelton, Jonathan E.;
- Bonaventure, Pascal;
- Letavic, Michael A.;
- Shireman, Brock T.;
- Lovenberg, Timothy W.;
- Dugovic, Christine
Publication type:
Article

Found: 33

OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.

OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO<sub>2</sub>-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.

Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors.

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.

Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7.

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System.

Relaxin Family Peptides and Receptors in Mammalian Brain.

Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope.

In Vitro Pharmacological Characterization of RXFP3 Allosterism: An Example of Probe Dependency.

Pharmacological Blockade of Serotonin 5-HT<sub>7</sub> Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission.

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.

Characterization of tritiated JNJ‐GluN2B‐5 (3‐[<sup>3</sup>H] 1‐(azetidin‐1‐yl)‐2‐(6‐(4‐fluoro‐3‐methyl‐phenyl)pyrrolo[3,2‐b]pyridin‐1‐yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors

Recent Progress in Relaxin-3--Related Research.

Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids.

Mapping of serotonin 5-HT<sub>4</sub> receptor mRNA and ligand binding sites in the post-mortem human brain.

Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice.

Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex.

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.

Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement.

JNJ-39220675, a novel selective histamine H receptor antagonist, reduces the abuse-related effects of alcohol in rats.

In vitro and in vivo characterization of JNJ-31020028 ( N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y<sub>2</sub> receptor

PET Brain Imaging of Neuropeptide Y2 Receptors Using N-<sup>11</sup>C-Methyl-JNJ-31020028 in Pigs.

Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex.

In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist.

Identification and characterization of select oxysterols as ligands for GPR17.

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

G-Protein-Coupled Receptor (GPCR)-142 Does Not Contribute to Relaxin-3 Binding in the Mouse Brain: Further Support that Relaxin-3 Is the Physiological Ligand for GPCR135.

Distribution of G-Protein-Coupled Receptor (GPCR)135 Binding Sites and Receptor mRNA in the Rat Brain Suggests a Role for Relaxin-3 in Neuroendocrine and Sensory Processing.

GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.

In vivo Calcium Imaging Reveals That Cortisol Treatment Reduces the Number of Place Cells in Thy1-GCaMP6f Transgenic Mice.

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.