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- Title
Vitamin K and Sphingolipid Metabolism: Evidence to Date.
- Authors
Denisova, Natalia A.; Booth, Sarah L.
- Abstract
The brain is enriched with sphingolipids, which are important membrane constituents and major lipid signaling molecules that have a role in motor and cognitive behavior. Vitamin K has been implicated in brain sphingolipid metabolism for more than 30 years. The in vitro and in vivo studies to date suggest a role of vitamin K in the regulation of multiple enzymes involved in sphingolipid metabolism within the myelin-rich regions in the brain. However, the precise mechanisms of action are not well understood. Further, the physiological consequences of the observed effects of vitamin K on sphingolipid metabolism have not been systematically studied.
- Subjects
VITAMIN K; SPHINGOLIPIDS; METABOLISM; EVIDENCE; ENZYMES; PHYSIOLOGY
- Publication
Nutrition Reviews, 2005, Vol 63, Issue 4, p111
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1111/j.1753-4887.2005.tb00129.x