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- Title
Expanding Chemical Frontiers: Approaches for Generating Diverse and Bioactive Natural Product‐Like Compounds Libraries from Extracts.
- Authors
Beato, Aurélien; Haudecoeur, Romain; Boucherle, Benjamin; Peuchmaur, Marine
- Abstract
The realms of natural products and synthetic compounds exhibit distinct chemical spaces that not only differ but also complement each other. While the convergence of these two domains has been explored through semisynthesis and conventional pharmacomodulation endeavours applied to natural frameworks, a recent and innovative approach has emerged that involves the combinatorial generation of libraries of 'natural product‐like compounds' (NPLCs) through the direct synthetic derivatization of natural extracts. This has led to the production of numerous NPLCs that incorporate structural elements from both their natural (multiple saturated rings, oxygen content, chiral centres) and synthetic (aromatic rings, nitrogen and halogen content, drug‐like properties) precursors. Through careful selection of extracts and reagents, specific bioactivities have been achieved, and this strategy has been deployed in various ways, showing great promise without reaching its full potential to date. This review seeks to provide an overview of reported examples involving the chemical engineering of extracts, showcasing a spectrum of natural product alterations spanning from simple substitutions to complete scaffold remodelling. It also includes an analysis of the accomplishments, perspectives and technical challenges within this field.
- Subjects
CHEMICAL libraries; SYNTHETIC products; NATURAL products; CHEMICAL engineering; CHEMICAL engineers; NITROGEN
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 26, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202304166