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- Title
Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia.
- Authors
Bhat, Vasudeva K.; Sharma, Ratna A.; Sharma, Sujata M.; Joshi, Priyanka; Dias, Bina F.; Shah, Nikita; Setia, Maninder; Manglani, Mamta V.
- Abstract
Objectives: To study vitamin C levels in children with transfusion-dependent β-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients. Methods: This case-control study enrolled 100 children with transfusion-dependent β-thalassemia and 30 healthy controls. MDA levels before and after administration of vitamin C were performed randomly in 36 children with low vitamin C levels. Results: 81/95 (85.3%) study subjects vs none in control group, had low plasma vitamin C levels (P<0.001). Vitamin C levels were low in 64 of 71 (74.7%) subjects with dietary deficiency, while none of the 19 (63.3%) controls with dietary deficiency had low levels (P=0.04). Increasing serum ferritin values correlated with vitamin C deficiency (P=0.02). The mean level of MDA reduced (P<0.001) with vitamin C supplementation. Conclusions: Low levels of vitamin C are common in children with thalassemia. Dietary counseling along with supplementation with vitamin C, in those with low levels may prevent oxidative stress.
- Subjects
VITAMIN C deficiency; NUTRITION counseling; VITAMIN C; DIETARY supplements; OXIDIZING agents
- Publication
Indian Pediatrics, 2021, Vol 58, Issue 7, p631
- ISSN
0019-6061
- Publication type
Article
- DOI
10.1007/s13312-021-2257-8